Guayama ) is a municipality of Puerto Rico founded on January 29, 1736 and located on the Southern Coastal Valley region, bordering the Caribbean, south of Cayey; east of Salinas; and west of Patillas and Arroyo. Guayama is spread over 9 wards and Guayama Pueblo (The downtown area and the administrative center of the city). It is the principal city of the Guayama Metropolitan Statistical Area.According to the 2010 census, the city has a population of 45,372.