Montepulciano is a medieval and Renaissance hill town and comune in the province of Siena in southern Tuscany, in Italy. Montepulciano, with an elevation of 605 m, sits on a high limestone ridge. By car it is 13 km E of Pienza; 70 km SE of Siena, 124 km SE of Florence, and 186 km north of Rome.Montepulciano is a major producer of food and drink. Montepulciano is known world-wide for its fabulous wine. Wine connoisseurs consider its Vino Nobile among Italy's best. However, the Vino Nobile di Montepulciano should not be confused with the varietal wine (Montepulciano grape) of the same name. Montepulciano is also known for its pork, cheese, "pici" pasta (a thick, rough, chewy variant on spaghetti), lentils, and honey.