Owensboro is the fourth largest city by population in the U.S. state of Kentucky. It is the county seat of Daviess County. It is located on U.S. Route 60 about 32 mi southeast of Evansville, Indiana and is the principal city of the Owensboro, Kentucky Metropolitan Statistical Area. The population was 57,265 at the 2010 U.S. Census Estimate. The city was named after Colonel Abraham Owen. Owensboro is the second-largest city in the Tri-State region of Illinois, Indiana, and Kentucky after Evansville, Indiana.