Salisbury is a city in southeastern Maryland, United States. It is the county seat of Wicomico County, Maryland and the largest city in Maryland's Eastern Shore region. The city's population was 23,743 at the 2000 census. Salisbury is the principal city of the Salisbury, Maryland Metropolitan Statistical Area, which is part of the Salisbury-Ocean Pines, Maryland Combined Statistical Area. The city is the commercial hub of the Delmarva Peninsula and is sometimes called "the Crossroads of Delmarva".Salisbury is located near several major cities: Baltimore 106 mi; Washington, D.C. 119 mi, Philadelphia 128 mi, Norfolk 132 mi, Dover 50 mi, and Wilmington 96 mi.