Shamrock is a city in Wheeler County, Texas, United States. As of the 2000 census, the city had a total population of 2,029. The city is located in the eastern portion of the Texas Panhandle centered along the crossroads of Interstate 40 (formerly U.S. Route 66) and U.S. Route 83. It is 110 mi east of Amarillo, 188 mi west of Oklahoma City, Oklahoma, and 291 mi northwest of Dallas.