Winston-Salem is a city in the U.S. state of North Carolina, with a 2010 population of 229,617. Winston-Salem is the county seat and largest city of Forsyth County and the fourth-largest city in the state. Winston-Salem is the second largest municipality in the Piedmont Triad region and is home to the tallest office buildings in the region, such as 100 North Main Street. It is called the "Twin City" for its dual heritage and "City of the Arts" for its dedication to fine arts and theater. "Camel City" is an historic reference to city's involvement in the tobacco industry. Many locals use "Winston" in informal speech. Other city nicknames include "The Dash" which is the name of the city's minor league baseball team and refers to the hyphen between "Winston" and "Salem". Winston-Salem is home to three universities and one college: Wake Forest University, a nationally distinguished private university, Winston-Salem State University, a historically black university founded in 1892, the University of North Carolina School of the Arts, and Salem College, a four-year liberal arts college for women.In 2003, the previous Greensboro - Winston-Salem - High Point metropolitan statistical area (MSA) was re-defined by the U.S. Office of Management and Budget, resulting in the formation of the Greensboro-High Point MSA and the Winston-Salem MSA. The 2009 population estimate for the Winston-Salem, North Carolina MSA was 484,921. The Greensboro - Winston-Salem - High Point combined statistical area (CSA), popularly referred to as the Piedmont Triad, had an estimated population of 1,581,122 in 2009 making it the 30th largest metropolitan area in the USA. Source: US Bureau of the Census, Annual Estimates of the Population Table CBSA-EST2007-02. It is one of the state's most affluent communities.